Periosteum: biology, regulation, and response to osteoporosis therapies
نویسندگان
چکیده
منابع مشابه
Is it time to combine osteoporosis therapies?
www.thelancet.com Published online May 15, 2013 http://dx.doi.org/10.1016/S0140-6736(13)60984-8 1 Some therapies licensed to treat osteoporosis work by inhibiting bone turnover (anticatabolic agents) and some by stimulating bone formation (anabolic agents). In The Lancet, Joy Tsai and colleagues report an exciting new approach in which an anticatabolic drug, denosumab, is combined with an anabo...
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Although several effective therapies are available for the treatment of osteoporosis in postmenopausal women and older men, there remains a need for the development of even more effective and acceptable drugs. Several new drugs that are in late-stage clinical development will be discussed. Abaloparatide (recombinant parathyroid hormone related peptide [PTHrP] analogue) has anabolic activity lik...
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The periosteum is a thin layer of connective tissue that covers the outer surface of a bone in all places except at joints (which are protected by articular cartilage). As opposed to bone itself, it has nociceptive nerve endings, making it very sensitive to manipulation. It also provides nourishment in the form of blood supply to the bone. The periosteum is connected to the bone by strong colla...
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[This corrects the article DOI: 10.4061/2010/318320.].
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Microgravity causes changes in physiological systems that are both detrimental to human health and valuable for biomedical research. Some of the most pronounced and long-term changes occur in skeletal tissue, which experiences a profound and rapid wasting. Finding a countermeasure to the bone atrophy associated with weightlessness is necessary before long-duration human space exploration can be...
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ژورنال
عنوان ژورنال: Bone
سال: 2004
ISSN: 8756-3282
DOI: 10.1016/j.bone.2004.07.014